
Biological mechanisms regulating sleep
Sleep occupies about a third of human life and is a physiological state tightly regulated by homeostatic and circadian mechanisms. Whilst the circadian process tells us when is the best time to go to sleep, the homeostatic process regulates sleep intensity and duration. The longer we stay awake, the more intense the following sleep. We are particularly interested in understanding how the brain keeps track of waking experience's richness and duration and translates it into the need for a deeper, longer sleep. Our research is focused on the brain circuits and molecular mechanisms involved in sleep homeostasis.
We hope to apply this knowledge to treat mental conditions in which sleep homeostasis is impaired.
